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This speed can be critical, especially for individuals with poorly controlled glucose levels

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Unlike small molecules synthesized in a single step, Semaglutide is first expressed as a precursor or fusion construct, then enzymatically processed with surgical precision to generate the exact therapeutic peptide backbone before any downstream chemical modification takes place

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doi: 10.3389/fimmu.2026.1704717 Received 13 September 2025 Revised 05 January 2026 Accepted 14 January 2026 Published 02 February 2026 Volume 17 - 2026 Edited by Pankaj Dipankar, National Institutes of Health (NIH), United States Reviewed by Shanid Mohiyuddin, University of Missouri, United States Diego Salazar, National Institutes of Health (NIH), United States Updates Copyright 2026 Lv, Cao, Zhao, Yang, Ma, Zhang, Wu, Chen and Gao